abstract：:We report the characterization of 16 polymorphic microsatellite markers in the golden apple snail, Pomacea canaliculata, a pest registered in the list of "100 of the world's worst invasive alien species". The fast isolation by AFLP (Amplified Fragment Length Polymorphism) of sequences containing repeats (FIASCO) metho...

journal_title：International journal of molecular sciences

authors： Chen L,Xu H,Li H,Wu J,Ding H,Liu Y

更新日期：2011-01-01 00:00:00

abstract：:The objective of the study was to evaluate oxidative stress (OS) status in subjects with different cardiovascular risk factors. With this in mind, we have studied three models of high cardiovascular risk: hypertension (HT) with and without metabolic syndrome, familial hypercholesterolemia (FH) and familial combined hy...

journal_title：International journal of molecular sciences

authors： Mansego ML,Redon J,Martinez-Hervas S,Real JT,Martinez F,Blesa S,Gonzalez-Albert V,Saez GT,Carmena R,Chaves FJ

更新日期：2011-01-01 00:00:00

abstract：:Glutathione synthetases catalyze the ATP-dependent synthesis of glutathione from l-γ-glutamyl- l-cysteine and glycine. Although these enzymes have been sequenced and characterized from a variety of biological sources, their exact catalytic mechanism is not fully understood and nothing is known about their adaptation a...

journal_title：International journal of molecular sciences

authors： Merlino A,Russo Krauss I,Albino A,Pica A,Vergara A,Masullo M,De Vendittis E,Sica F

更新日期：2011-01-01 00:00:00

abstract：:Analbuminemia is a rare autosomal recessive disorder manifested by the absence, or severe reduction, of circulating serum albumin (ALB). We report here a new case diagnosed in a 45 years old man of Southwestern Asian origin, living in Switzerland, on the basis of his low ALB concentration (0.9 g/L) in the absence of r...

journal_title：International journal of molecular sciences

authors： Dagnino M,Caridi G,Haenni U,Duss A,Aregger F,Campagnoli M,Galliano M,Minchiotti L

更新日期：2011-01-01 00:00:00

abstract：:Sequence diversity and population structures can vary widely among pathogenic bacteria species. In some species, all isolates are highly similar, whereas in others most of the isolates are distinguished easily. H. pylori is known for its wide genetic diversity amongst the various strains most especially in the genes i...

journal_title：International journal of molecular sciences

authors： Tanih NF,Ndip LM,Ndip RN

更新日期：2011-01-01 00:00:00

abstract：:Experiments were carried out to investigate the effects of various factors on the activity and conformation of recombinant leucine aminopeptidase of Bacillus kaustophilus CCRC 11223 (BkLAP) and potential utilization of BkLAP in the hydrolysis of anchovy protein. Optimal temperature and pH of BkLAP were 70 °C and 8.0 i...

journal_title：International journal of molecular sciences

authors： Shen Y,Wang F,Lan D,Liu Y,Yang B,Wang Y

更新日期：2011-01-01 00:00:00

abstract：:In recent decades, serious contamination of soils by heavy metals has been reported. It is therefore a matter of urgency to develop a new and efficient technology for removing contaminants from soil. Another aspect to this problem is that environmental pollution decreases the biological quality of soil, which is why p...

journal_title：International journal of molecular sciences

authors： Szczygłowska M,Piekarska A,Konieczka P,Namieśnik J

更新日期：2011-01-01 00:00:00

abstract：:Rhizobia are Gram-negative bacteria that can exist either as free-living bacteria or as nitrogen-fixing symbionts inside root nodules of leguminous plants. The composition of the rhizobial outer surface, containing a variety of polysaccharides, plays a significant role in the adaptation of these bacteria in both habit...

journal_title：International journal of molecular sciences

authors： Janczarek M

更新日期：2011-01-01 00:00:00

abstract：:This study evaluates the pre-treatment of cellulose from kenaf plant to yield sugar precursors for the production of ethanol or butanol for use as biofuel additives. In order to convert the crystalline cellulosic form to the amorphous form that can undergo enzymatic hydrolysis of the glycosidic bond to yield sugars, k...

journal_title：International journal of molecular sciences

authors： Ooi BG,Rambo AL,Hurtado MA

更新日期：2011-01-01 00:00:00

abstract：:In eukaryotes, DNA is compacted into a complex structure known as chromatin. The unravelling of DNA is a crucial step in DNA repair, replication, transcription and recombination as this allows access to DNA for these processes. Failure to package DNA into the nucleosome, the individual unit of chromatin, can lead to g...

journal_title：International journal of molecular sciences

authors： Farrell AW,Halliday GM,Lyons JG

更新日期：2011-01-01 00:00:00

abstract：:Aurora kinases have emerged as attractive targets for the design of anticancer drugs. 3D-QSAR (comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)) and Surflex-docking studies were performed on a series of pyrrole-indoline-2-ones as Aurora A inhibitors. The CoMFA...

journal_title：International journal of molecular sciences

authors： Ai Y,Wang ST,Sun PH,Song FJ

更新日期：2011-01-01 00:00:00

abstract：:Tissue engineering is an emerging field of research which combines the use of cell-seeded biomaterials both in vitro and/or in vivo with the aim of promoting new tissue formation or regeneration. In this context, how cells colonize and interact with the biomaterial is critical in order to get a functional tissue engin...

journal_title：International journal of molecular sciences

authors： Sanz-Herrera JA,Reina-Romo E

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to investigate the feasibility and advantages of constructing a novel tissue engineering bone, using β-tricalcium phosphate (β-TCP) and rat bone marrow mesenchymal stem cells (MSCs), modified with human bone morphogenetic protein 2 gene (hBMP2) and human vascular endothelial growth factor...

journal_title：International journal of molecular sciences

authors： Jiang J,Fan CY,Zeng BF

更新日期：2011-01-01 00:00:00

abstract：:Chitosan is an amino polysaccharide found in nature, which is biodegradable, nontoxic and biocompatible. It has versatile features and can be used in a variety of applications including films, packaging, and also in medical surgery. Recently a possibility to diversify chitosan properties has emerged by combining it wi...

journal_title：International journal of molecular sciences

authors： Espíndola-González A,Martínez-Hernández AL,Fernández-Escobar F,Castaño VM,Brostow W,Datashvili T,Velasco-Santos C

更新日期：2011-01-01 00:00:00

abstract：:Expression of human granulocyte macrophage colony stimulating factor (hGMCSF), a cytokine of therapeutic importance, as a thioredoxin (TRX) fusion has been investigated in Escherichia coli BL21 (DE3) codon plus cells. The expression of this protein was low when cloned under the T7 promoter without any fusion tags. Hig...

journal_title：International journal of molecular sciences

authors： Das KM,Banerjee S,Shekhar N,Damodaran K,Nair R,Somani S,Raiker VP,Jain S,Padmanabhan S

更新日期：2011-01-01 00:00:00

abstract：:Aerobic metabolism occurs in a background of oxygen radicals and reactive oxygen species (ROS) that originate from the incomplete reduction of molecular oxygen in electron transfer reactions. The essential role of aerobic metabolism, the generation and consumption of ATP and other high energy phosphates, sustains a ba...

journal_title：International journal of molecular sciences

authors： Liu J,Litt L,Segal MR,Kelly MJ,Pelton JG,Kim M

更新日期：2011-01-01 00:00:00

abstract：:We built new hybrid devices consisting of chemical vapor deposition (CVD) grown carbon nanotube (CNT) transistors, decorated with TbPc(2) (Pc = phthalocyanine) rare-earth based single-molecule magnets (SMMs). The drafting was achieved by tailoring supramolecular π-π interactions between CNTs and SMMs. The magnetoresis...

journal_title：International journal of molecular sciences

authors： Urdampilleta M,Nguyen NV,Cleuziou JP,Klyatskaya S,Ruben M,Wernsdorfer W

更新日期：2011-01-01 00:00:00

abstract：:Acipenseriformes are composed of 25 sturgeon species and two paddlefish species distributed exclusively in the northern hemisphere. The Danube River and the Black Sea were originally inhabited by six sturgeon species but two are extinct and only four are still reproducing currently in the Lower Danube: Huso huso, Acip...

journal_title：International journal of molecular sciences

authors： Dudu A,Suciu R,Paraschiv M,Georgescu SE,Costache M,Berrebi P

更新日期：2011-01-01 00:00:00

abstract：:Four chiral Schiff base binuclear 3d-4f complexes (NdNi, NdCu, GdNi, and GdCu) have been prepared and characterized by means of electronic and CD spectra, IR spectra, magnetic measurements, and X-ray crystallography (NdNi). A so-called artifact peak of solid state CD spectra, which was characteristic of oriented molec...

journal_title：International journal of molecular sciences

authors： Okamoto Y,Nidaira K,Akitsu T

更新日期：2011-01-01 00:00:00

abstract：:Mitochondria are involved either directly or indirectly in oncogenesis and the alteration of metabolism in cancer cells. Cancer cells contain large numbers of abnormal mitochondria and produce large amounts of reactive oxygen species (ROS). Oxidative stress is caused by an imbalance between the production of ROS and t...

journal_title：International journal of molecular sciences

authors： Song IS,Kim HK,Jeong SH,Lee SR,Kim N,Rhee BD,Ko KS,Han J

更新日期：2011-01-01 00:00:00

abstract：:Winter's advent invokes physiological adjustments that permit temperate ectotherms to cope with stresses such as food shortage, water deprivation, hypoxia, and hypothermia. We used liquid chromatography (LC) in combination with tandem mass spectrometry (MS/MS) quantitative isobaric (iTRAQ™) peptide mapping to assess v...

journal_title：International journal of molecular sciences

authors： Kiss AJ,Muir TJ,Lee RE Jr,Costanzo JP

更新日期：2011-01-01 00:00:00

abstract：:Living organisms heavily rely on the function of motor circuits for their survival and for adapting to ever-changing environments. Unique among central nervous system (CNS) neurons, motor neurons (MNs) project their axons out of the CNS. Once in the periphery, motor axons navigate along highly stereotyped trajectories...

journal_title：International journal of molecular sciences

authors： Bravo-Ambrosio A,Kaprielian Z

更新日期：2011-01-01 00:00:00

abstract：:Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a promising target for developing novel anticancer drugs. A combined molecular docking, structure-based pharmacophore modeling and three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on ...

journal_title：International journal of molecular sciences

authors： Lu S,Liu HC,Chen YD,Yuan HL,Sun SL,Gao YP,Yang P,Zhang L,Lu T

更新日期：2011-01-01 00:00:00

abstract：:The solvatochromic characteristics of flavone and 7-hydroxyflavone were investigated in neat and binary solvent mixtures. The spectral shifts of these solutes were correlated with the Kamlet and Taft parameters (α, β and π*) using linear solvation energy relationships. The multiparametric analysis indicates that both ...

journal_title：International journal of molecular sciences

authors： Sancho MI,Almandoz MC,Blanco SE,Castro EA

更新日期：2011-01-01 00:00:00

abstract：:Saturated aqueous solutions of various common salts were examined for their effect on aqueous aldol reactions catalysted by a highly active C(2)-symmetric diprolinamide organocatalyst developed in our laboratory. With respect to the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde, deionised water was alwa...

journal_title：International journal of molecular sciences

authors： Delaney JP,Henderson LC

更新日期：2011-01-01 00:00:00

abstract：:In this study, the effect of the acetone extract of Arctotis arctotoides (L.f.) O. Hoffm. (Asteraceae) on the growth and ultrastructure of some opportunistic fungi associated with HIV/AIDS was analyzed by means of scanning electron microscope (SEM). Remarkable morphological alterations in the fungal mycelia which were...

journal_title：International journal of molecular sciences

authors： Otang WM,Grierson DS,Ndip RN

更新日期：2011-01-01 00:00:00

abstract：:We review the recent development of chiral sum frequency generation (SFG) spectroscopy and its applications to study chiral vibrational structures at interfaces. This review summarizes observations of chiral SFG signals from various molecular systems and describes the molecular origins of chiral SFG response. It focus...

journal_title：International journal of molecular sciences

authors： Fu L,Wang Z,Yan EC

更新日期：2011-01-01 00:00:00

abstract：:Metal compounds such as arsenic, cadmium, chromium, cobalt, lead, mercury, and nickel are classified as carcinogens affecting human health through occupational and environmental exposure. However, the underlying mechanisms involved in tumor formation are not well clarified. Interference of metal homeostasis may result...

journal_title：International journal of molecular sciences

authors： Koedrith P,Seo YR

更新日期：2011-01-01 00:00:00

abstract：:Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated....

journal_title：International journal of molecular sciences

authors： Ge Y,Zhang Y,Chen Y,Li Q,Chen J,Dong Y,Shi W

更新日期：2011-01-01 00:00:00

abstract：:2-Bromopropane (2-BP) is used as an alternative to ozone-depleting cleaning solvents. Previously, we reported that 2-BP has cytotoxic effects on mouse blastocysts and is associated with defects in subsequent development. In the present work, we show that 2-BP induces apoptosis in the inner cell mass of mouse blastocys...

journal_title：International journal of molecular sciences

authors： Chan WH

更新日期：2011-01-01 00:00:00

abstract：:Bacterial outer membrane proteins, along with a filling lipid molecule can be modified to form stable self-assembled monolayers on gold. The transmembrane domain of Escherichia coli outer membrane protein A has been engineered to create a scaffold protein to which functional motifs can be fused. In earlier work we des...

journal_title：International journal of molecular sciences

authors： Le Brun AP,Shah DS,Athey D,Holt SA,Lakey JH

更新日期：2011-01-01 00:00:00

abstract：:Following major advances in the field of medicinal chemistry, novel drugs can now be designed systematically, instead of relying on old trial and error approaches. Current drug design strategies can be classified as being either ligand- or structure-based depending on the design process. In this paper, by describing t...

journal_title：International journal of molecular sciences

authors： Lee CH,Huang HC,Juan HF

更新日期：2011-01-01 00:00:00

abstract：:Alfalfa is an autotetraploid, allogamous and heterozygous forage legume, whose varieties are synthetic populations. Due to the complex nature of the species, information about genetic diversity of germplasm used in any alfalfa breeding program is most beneficial. The genetic diversity of five alfalfa varieties, involv...

journal_title：International journal of molecular sciences

authors： Nagl N,Taski-Ajdukovic K,Barac G,Baburski A,Seccareccia I,Milic D,Katic S

更新日期：2011-01-01 00:00:00

abstract：:In order to supply new information on the antioxidant function of selected beverages for nutritionists and the general public, total phenolic contents of 51 kinds of herbal and tea infusions made in China were measured by the Folin-Ciocalteu method, and their antioxidant capacities were evaluated using ferric reducing...

journal_title：International journal of molecular sciences

authors： Fu L,Xu BT,Gan RY,Zhang Y,Xu XR,Xia EQ,Li HB

更新日期：2011-01-01 00:00:00

abstract：:In this article we propose a systematic development method for rational drug design while reviewing paradigms in industry, emerging techniques and technologies in the field. Although the process of drug development today has been accelerated by emergence of computational methodologies, it is a herculean challenge requ...

journal_title：International journal of molecular sciences

authors： Williams CH,Hong CC

更新日期：2011-01-01 00:00:00

abstract：:Hypoxia is a common environmental stress factor and is associated with fibrogenesis. Matrix metalloproteinase-2 (MMP-2), produced by hepatic stellate cells (HSCs), plays an important role in liver fibrogenesis. However, inconsistent results have been reported on the impact of hypoxia on MMP-2 expression and activity i...

journal_title：International journal of molecular sciences

authors： Li J,Fan R,Zhao S,Liu L,Guo S,Wu N,Zhang W,Chen P

更新日期：2011-01-01 00:00:00

abstract：:A systematic study of the effect of composition on the thermo-physical properties of the binary mixtures of 1-methyl-3-pentyl imidazolium hexafluorophosphate [MPI][PF(6)] with poly(ethylene glycol) (PEG) [M(w) = 400] is presented. The excess molar volume, refractive index deviation, viscosity deviation, and surface te...

journal_title：International journal of molecular sciences

authors： Wu TY,Chen BK,Hao L,Peng YC,Sun IW

更新日期：2011-01-01 00:00:00

abstract：:The aim of study is to identify cisplatin-resistance associated biomarkers for non-small cell lung cancers (NSCLC). We use two-dimensional electrophoresis (2-DE) combined with MALDI-TOF mass spectrometry to compare the proteome between lung cancer cell line A549 and its cisplatin-resistant subline A549/DDP. Nine cispl...

journal_title：International journal of molecular sciences

authors： Zeng HZ,Qu YQ,Zhang WJ,Xiu B,Deng AM,Liang AB

更新日期：2011-01-01 00:00:00

abstract：:Micro Electromechanical Systems (MEMS) based microfluidic devices have gained popularity in biomedicine field over the last few years. In this paper, a comprehensive overview of microfluidic devices such as micropumps and microneedles has been presented for biomedical applications. The aim of this paper is to present ...

journal_title：International journal of molecular sciences

authors： Ashraf MW,Tayyaba S,Afzulpurkar N

更新日期：2011-01-01 00:00:00

abstract：:Tryptanthrin, a kind of indole quinazoline alkaloid, has been shown to exhibit anti-microbial, anti-inflammation and anti-tumor effects both in vivo and in vitro. However, its biological activity on human chronic myeloid leukemia cell line K562 is not fully understood. In the present study, we investigated the prolife...

journal_title：International journal of molecular sciences

authors： Miao S,Shi X,Zhang H,Wang S,Sun J,Hua W,Miao Q,Zhao Y,Zhang C

更新日期：2011-01-01 00:00:00